Heritability

GWAS

Posted by Fei-Fei on May 1, 2020

heritability

Jencks Critique Genes may inflence outcomes through mechanisms that are modifiable: by evoking environmental responses by causing people to select into environments

#twin study twin study

sibling correlation

SNP-based heritability

HE-regression

regress phenotypic similarity of genetic similary phenotypic similarity= (y1-y2)^2 genetic similarity= GRM

GREML

likelihood(sigma(g),sigma(e) GRM, phenotype)= multivarite normal distribution

LDSC

heritability= (N*beta)^2/ldscore

SBeyesR