Paper reading

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Posted by Fei-Fei on April 3, 2020

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

Ying Wang, Jing Guo, Guiyan Ni, Jian Yang, Peter M. Visscher, Loic Yengo

昨天实验室technical meeting介绍了这篇文章。

主要结论是:Missing of perdiction accurancy in different ancestry is attributed by linkage disequilibrium (LD) and minus allele frequency (MAF), which can explain 70% missing of relative accurancy.